Figure 2.

Hepatocyte farnesoid X receptor (FXR) does not further potentiate acetaminophen (APAP) toxicity. A and B, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of APAP-treated Fxr^ΔHep mice and Fxr^fl/fl mice. C, Representative hematoxylin and eosin (H&E) staining of APAP-dosed Fxr^ΔHep mice and its matched Fxr^fl/fl mice, scale bar 100 µm. D and E, serum ALT and AST levels of untreated control Fxr^ΔHep mice and Fxr^fl/fl mice. F, Representative H&E staining of untreated control Fxr^ΔHep mice and Fxr^fl/fl mice, scale bar 100 µm (n = 5 mice per group). Data are presented as means ± SEM.