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. 2021 Feb 28;181(2):273–284. doi: 10.1093/toxsci/kfab027

Figure 3.

Figure 3.

Loss of macrophage farnesoid X receptor (FXR) expression does not further enhance acetaminophen (APAP)-induced toxicity. A, Breeding scheme of FxrΔMac mice. B, mRNA levels of Kupffer cell Fxr in FxrΔMac and Fxrfl/fl mice. C, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at 6 h after APAP dosing in FxrΔMac and Fxrfl/fl mice. D, serum ALT and AST levels at 24 h after APAP dosing in FxrΔMac and Fxrfl/fl mice. E, hematoxylin and eosin (H&E) staining of liver sections from APAP-dosed FxrΔMac and Fxrfl/fl mice; scale bar 100 µm. F and G, serum ALT and AST levels of untreated control FxrΔMac and Fxrfl/fl mice. H, H&E staining of liver sections from untreated control FxrΔMac and Fxrfl/fl mice; scale bar 50 µm (n = 4 for Figure 3B, whereas n = 5 mice per group for Figs. 3C–H). Data are presented as means ± SEM. ***p < .005 compared with the Fxrfl/fl group.