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. 2021 Feb 28;181(2):273–284. doi: 10.1093/toxsci/kfab027

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Published by Oxford University Press on behalf of the Society of Toxicology 2021.

This work is written by US Government employees and is in the public domain in the US.

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Figure 4. — Bile acids accumulates more significantly in global farnesoid X receptor (Fxr)-null mice than Fxr^ΔHep mice after acetaminophen (APAP) dosing. A, serum free bile acids at 24 h after APAP dosing. B, Serum conjugated bile acids at 24 h after APAP dosing (n = 5 mice per group). Data are presented as means ± SEM. *p < .05, **p < .01, and ***p < .005 compared with wild-type group. #p < .05, ##p < .01, and ###p < .005 compared with the Fxr^ΔHep group. Abbreviations: CA, cholic acid; α-MCA, α-muricholic acid; βMCA, β-muricholic acid; DCA, deoxycholic acid; UDCA, ursodeoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; TCA, taurocholic acid; TαMCA, tauro-α-muricholic acid; TβMCA, tauro-β-muricholic acid; TDCA, taurodeoxycholic acid; TCDCA, taurochenodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; THDCA, taurohyodeoxycholic acid.