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. 2021 Feb 28;181(2):273–284. doi: 10.1093/toxsci/kfab027

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Published by Oxford University Press on behalf of the Society of Toxicology 2021.

This work is written by US Government employees and is in the public domain in the US.

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Figure 8. — Tumor necrosis factor-α (TNF-α) antagonist infliximab (INF) decreases serum TNF-α levels and alleviated deoxycholic acid (DCA)/acetaminophen (APAP)-induced liver injury. A, Time scheme of experiment procedure. B, Serum TNF-α levels. C, Serum alanine aminotransferase levels. D, Serum aspartate aminotransferase levels. E, Hepatic hematoxylin and eosin staining; 100 times scale bar 100 µm. F, Graphic abstract of proposed mechanism (n = 6 mice per group). Data are presented as means ± SEM. Control, control saline-treated mice; APAP+DCA, mice pretreated with saline for three consecutive days, adminstered with APAP + DCA; INF, INF only treated group; INF + APAP/DCA, mice pretreated with INF for three consecutive days, and then treated with APAP+DCA. *p < .05, **p < .01, and ***p < .005, compared with Saline + A/D group. #p < .05, ##p < .01, and ###p < .005 compared with control group.