Table 2.
Subgroup Analysis of Xpert Ultra on Children in Kampala, Uganda
| Confirmed TBa | Unlikely TBa | Sensitivity n/N, % (95% CI) | Specificity n/N, % (95% CI) | Difference in Sensitivity % (95% CI) | P-valueb | |
|---|---|---|---|---|---|---|
| Age under 5 years | 11 | 63 | 7/11, 63.6% (30.8 to 89.1) | 63/63, 100% (94.3 to 100) | 11.4% (−26.2 to 48.9) | .55 |
| Age 5-14 years | 12 | 39 | 9/12, 75.0% (42.8 to 94.5) | 39/39, 100% (91.0 to 100) | ||
| Smear microscopy positive | 13 | 0 | 12/13, 92.3% (64 to 99.8) | — | 52.3% (18.7 to 85.9) | .01 |
| Smear microscopy negative | 10 | 102 | 4/10, 40% (12.2 to 73.8) | 102/102, 100% (96.4 to 100) | ||
| Underweight | 19 | 56 | 13/19, 68.4% (43.4 to 87.4) | 56/56, 100% (93.6 to 100) | 6.6% (−40.7 to 53.9) | .79 |
| Normal weight | 4 | 46 | 3/4, 75% (19.4 to 99.4) | 46/46, 100% (92.3 to 100) | ||
| Expectorated/induced sputum | 15 | 61 | 12/15, 80% (51.9 to 95.7) | 61/61, 100% (94.1 to 100) | 30% (−10.1 to 70.1) | .14 |
| Gastric/nasopharyngeal aspirate | 8 | 41 | 4/8, 50% (15.7 to 84.3) | 41/41, 100% (91.4 to 100) |
Abbreviations: TB, tuberculosis; CI, confidence interval.
aDefined per the NIH consensus definitions [15].
b P-value determined using proportion testing.