Minimum inhibitory concentrations (MICs) of pladienolide B (1) and its congeners (2–6) against NS-1 mouse myeloma ATCC TIB-18 and NFF human neonatal foreskin fibroblast cells ATCC PCS-201.
| Compound | MIC (μg mL−1) | |
|---|---|---|
| NS-1 | NFF | |
| 1 | 0.001 | 0.013 |
| 2 | 0.001 | 0.04 |
| 3 | 0.05 | 0.6 |
| 4 | 0.1 | 0.4 |
| 5 | 0.63 | 10 |
| 6 | 0.08 | 1.25 |