IC50 values of pladienolide B (1) and its analogues (2–5) against mammalian cell lines: (NS-1 mouse myeloma ATCC TIB-18, DU145 human prostate cancer cell ATCC HTB-81 and NFF human neonatal foreskin fibroblast cells ATCC PCS-201). ND denotes no data.
| Compound | IC50 (μM) ± 95% confidence interval | ||
|---|---|---|---|
| NS-1 | DU145 | NFF | |
| 1 | 5.6 ± 0.6 | 7.5 ± 3.5 | 13.0 ± 4.1 |
| 2 | 40.3 ± 3.7 | 9.6 ± 5.8 | 27 ± 14 |
| 3 | >770 | 96 ± 27 | 319 ± 61 |
| 4 | >790 | 264 ± 79 | >790 |
| 5 | ND | ND | 8100 ± 1800 |