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. Author manuscript; available in PMC: 2021 Oct 19.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Aug 26;59(43):19143–19152. doi: 10.1002/anie.202006719

Fig. 5: Optimized quenched substrate probes can distinguish human breast cancer samples.

Fig. 5:

(A) Histology (Hematoxylin and eosin stain) of 5 patient biopsy samples of breast tumor tissue and adjacent healthy mammary tissue. (B) Quantification of cleavage rates of normal healthy human breast tissue (N) and human breast tumor tissue (T) incubated with 4–8 (nHealthy= 5, nTumor= 5, Student’s t-test). (C) Comparison of cleavage pattern of one representative human breast cancer sample (left), the murine 4T1 tumor lysate (middle), and recombinant cathepsin B (right) incubated with probed 4–8. Mean value ± SD. n=3.