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. 2021 Mar 13;35(3):1245–1254. doi: 10.1111/jvim.16097

FIGURE 7.

FIGURE 7

Hourly aldosterone‐related variables are shown during the furosemide continuous rate infusion (FCRI). A = placebo before FCRI, B = benazepril before FCRI, C = benazepril and spironolactone before FCRI. The large shaded box visually separates the treatments. For each plot, the colored box represents the 25th to 75th percentile, the bisecting line is the median, the symbol within the box is the mean, and the whiskers are the 5th to 95th percentiles. A, Plasma aldosterone increased over time for all treatments (P < .001). Hour 5 was significantly different from hour 0 (P < .001) and hour 1 (P = .04). No difference among treatments was noted (P = .08). B, Urine aldosterone : creatinine did not change over time (P = .72) or among treatments (P = .08). C, The uNa : uK ratio was significantly different over time (P < .001) with a pattern similar to urine production; however, no treatment differences were present (P = .74). All hours were significantly different from each other (P < .05) except hour 0 and hour 5 (P = .06) and hour 4 and hour 5 (P = .42)