TABLE 1.

Median and interquartile ranges for ACE activity (ACE; U/L) measured by radioenzymatic assay at hours 0, 5, and 24 for treatments A, B, and C are shown

	ACE (U/L) hour 0	ACE (U/L) hour 5	ACE (U/L) hour 24	P value
Treatment A	22.1 (19.3‐26.9); n = 9	25.0 (20.5‐37.3); n = 7	32.1 (25.7‐36.1); n = 9	.11
Treatment B	2.5 (2.5‐8.9) ^ ; n = 10	4.5 (2.5‐10.2); n = 8	25.0 (8.7‐30.2) * ; n = 9	.002
Treatment C	2.5 (2.5‐7.2) ^ ; n = 9	2.5 (2.5‐9.4) ^ ; n = 9	18.9 (15.1‐24.0) * , # , ^ ; n = 8	<.001
P value	<.001	.005	.008

Note: n = the number of samples available for analysis at each time point. P values in the right column indicate comparison among time points. P values in the bottom row indicate comparison among treatments. A = placebo before furosemide continuous rate infusion (FCRI), B = benazepril before FCRI, C = benazepril and spironolactone before FCRI. Hour 0 is after 3 days of PO treatment but before FCRI. Hour 5 is at the end of the FCRI. Hour 24 is 24 hours after the start of FCRI.

Abbreviation: ACE, angiotensin‐converting enzyme.

^* P < .05 compared to hour 0.

^# P < .05 compared to hour 5.

^{^} P < .05 compared to treatment A.