. 2021 May 14;8:657258. doi: 10.3389/fmolb.2021.657258

TABLE 2.

Selection of brain- and vasculature injury related miRNAs.

Assay ID	miRNA^a	Sequence	Relevance to aSAH and cerebral vasculature
000377	hsa-let-7a-5p^b	UGAGGUAGUAGGUUGUAUAGUU	Inflammatory/immune response
002619	hsa-let-7b-5p^b	UGAGGUAGUAGGUUGUGUGGUU	Angiogenesis/inflammatory and immune response
000379	hsa-let-7c-5p^b	UGAGGUAGUAGGUUGUAUGGUU	Inflammatory/immune response
000439	hsa-miR-103a-3p^b	AGCAGCAUUGUACAGGGCUAUGA	Cell migration/wound healing
000443	hsa-miR-107^b	AGCAGCAUUGUACAGGGCUAUCA	Inflammatory response/cell migration/wound healing
000449	hsa-miR-125b-5p^b	UCCCUGAGACCCUAACUUGUGA	Cell proliferation/neuronal Integrity
002884	hsa-miR-1274b^c	UCCCUGUUCGGGCGCCA	Potential normalizer (CSF)
002861	hsa-miR-1298-5p^b	UUCAUUCGGCUGUCCAGAUGUA	Neural regeneration
000457	hsa-miR-132-3p^b	UAACAGUCUACAGCCAUGGUCG	Vascular angiogenesis
000464	hsa-miR-142-3p^b	UGUAGUGUUUCCUACUUUAUGGA	Inflammatory and immune response
002248	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUACU	Inflammatory and immune response
002676	hsa-miR-144-3p^b	UACAGUAUAGAUGAUGUACU	Proliferation/apoptosis/oxidative stress
000468	hsa-miR-146a-5p^b	UGAGAACUGAAUUCCAUGGGUU	Inflammatory and immune response
001097	hsa-miR-146b-5p	UGAGAACUGAAUUCCAUAGGCU	Inflammatory and immune response
000473	hsa-miR-150-5p	UCUCCCAACCCUUGUACCAGUG	Inflammatory and immune response/BBB permeability
001191	hsa-miR-153-3p^b	UUGCAUAGUCACAAAAGUGAUC	Neurogenesis
002623	hsa-miR-155-5p^b	UUAAUGCUAAUCGUGAUAGGGGU	Inflammatory and immune response/arteriogenesis
000389	hsa-miR-15a-5p^b	UAGCAGCACAUAAUGGUUUGUG	Vascular angiogenesis
000390	hsa-miR-15b-5p^b	UAGCAGCACAUCAUGGUUUACA	Apoptosis/inflammatory response
000391	hsa-miR-16-5p^b	UAGCAGCACGUAAAUAUUGGCG	Vascular angiogenesis
002308	hsa-miR-17-5p^b	CAAAGUGCUUACAGUGCAGGUAG	Neovascularization/apoptosis/proliferation
000480	hsa-miR-181a-5p^b	AACAUUCAACGCUGUCGGUGAGU	Apoptosis/inflammatory response
000482	hsa-miR-181c-5p^b	AACAUUCAACCUGUCGGUGAGU	Apoptosis/inflammatory response
000494	hsa-miR-195-5p^b	UAGCAGCACAGAAAUAUUGGC	Homeostasis of vessel smooth muscle cells
000396	hsa-miR-19b-3p^b	UGUGCAAAUCCAUGCAAAACUGA	Neovascularization/apoptosis/proliferation
000508	hsa-miR-204-5p^b,c	UUCCCUUUGUCAUCCUAUGCCU	Apoptosis/proliferation
000580	hsa-miR-20a-5p^b	UAAAGUGCUUAUAGUGCAGGUAG	Neovascularization/apoptosis/proliferation
000397	hsa-miR-21-5p^b	UAGCUUAUCAGACUGAUGUUGA	Apoptosis/inflammatory
000524	hsa-miR-221-3p^b	AGCUACAUUGUCUGCUGGGUUUC	Apoptosis/inflammatory
002295	hsa-miR-223-3p^b	UGUCAGUUUGUCAAAUACCCCA	Inflammatory and immune response
000399	hsa-miR-23a-3p	AUCACAUUGCCAGGGAUUUCC	Mitochondrial function/apoptosis
000400	hsa-miR-23b-3p^b	AUCACAUUGCCAGGGAUUACC	Mitochondrial function/apoptosis
000402	hsa-miR-24-3p^b	UGGCUCAGUUCAGCAGGAACAG	Apoptosis/proliferation
000408	hsa-miR-27a-3p^b	UUCACAGUGGCUAAGUUCCGC	Autophagy/apoptosis
000409	hsa-miR-27b-3p^b	UUCACAGUGGCUAAGUUCUGC	Autophagy/apoptosis
002112	hsa-miR-29a-3p^b	UAGCACCAUCUGAAAUCGGUUA	Apoptosis/proliferation/immune response
000413	hsa-miR-29b-3p^b	UAGCACCAUUUGAAAUCAGUGUU	Apoptosis/proliferation/immune response
000587	hsa-miR-29c-3p^b	UAGCACCAUUUGAAAUCGGUUA	Apoptosis/proliferation/immune response
000426	hsa-miR-34a-5p^b	UGGCAGUGUCUUAGCUGGUUGU	Autophagy/inflammatory response
002102	hsa-miR-34b-3p^b	CAAUCACUAACUCCACUGCCAU	Autophagy/inflammatory response
001043	hsa-miR-497-5p	CAGCAGCACACUGUGGUUUGU	Apoptosis/inflammatory response
002268	hsa-miR-874-3p	CUGCCCUGGCCCGAGGGACCGA	Apoptosis/inflammatory response
000583	hsa-miR-9-5p^b	UCUUUGGUUAUCUAGCUGUAUGA	Neurogenesis and differentiation
000430	hsa-miR-92a-3p^b	UAUUGCACUUGUCCCGGCCUG	Neovascularization/apoptosis/proliferation
001182	hsa-miR-124-3p^b	UAAGGCACGCGGUGAAUGCC	Neurogenesis, differentiation, and inflammatory response
002571	mmu-miR-155-5p^d	UUAAUGCUAAUUGUGAUAGGGGU
001141	hsa-miR-451a^b	AAACCGUUACCAUUACUGAGUU	Apoptosis/inflammatory response/RBC enriched

^aAll selected miRNAs are known to be associated with CNS injuries or cerebral vasculature damage. ^bmiRNA has been implicated in biomarker studies related to CNS (TBI or SCI) or stroke. ^cmiRNA is a potential normalizer for CSF. ^dmmu-miR-155-5p was included for a separate unrelated rodent study.