TABLE 3.

Significant differential expression levels of brain and vasculature injury related miRNAs.

miRNA	CSF						Plasma
	I	II	III	IV	V	VI	I	II	III	IV	V	VI
let-7a-5p	**	ns	*	ns	ns	ns	**	**	ns	****	ns	***
let-7b-5p	***	ns	****	***	****	***	ns	ns	ns	*	ns	ns
let-7c-5p	**	ns	**	ns	*	*	ns	ns	ns	*	ns	ns
miR-103a-3p	*	ns	UD in heathy controls				ns	ns	ns	****	ns	**
miR-107	UD						***	*	***	ns	ns	*
miR-125b-5p	**	ns	**	ns	**	**	ns	ns	ns	ns	ns	ns
miR-1274b	*	ns	*	ns	**	**	**	ns	**	ns	**	ns
miR-1298-5p	ns	ns	ns	ns	**	ns	UD
miR-132-3p	**	ns	**	**	***	**	*	ns	ns	**	ns	ns
miR-142-3p	***	ns	****	***	***	****	**	*	ns	***	ns	*
miR-142-5p	***	ns	UD in heathy controls				*	ns	ns	**	ns	ns
miR-144-3p	UD						UD
miR-146a-5p	***	ns	****	***	****	***	**	ns	ns	****	ns	*
miR-146b-5p	**	ns	***	***	***	***	*	ns	ns	****	ns	**
miR-150-5p	**	ns	****	**	*	*	ns	ns	ns	**	ns	ns
miR-153-3p	UD						UD
miR-155-5p	ns	ns	ns	ns	ns	ns	**	*	ns	****	ns	***
miR-15a-5p	UD						**	ns	ns	**	ns	*
miR-15b-5p	****	ns	***	*	**	*	*	ns	ns	***	ns	**
miR-16-5p	***	ns	****	***	**	**	ns	ns	ns	ns	ns	ns
miR-17-5p	***	ns	****	***	**	**	*	ns	ns	*	ns	ns
miR-181a-5p	***	ns	*	ns	*	ns	**	ns	ns	***	ns	**
miR-181c-5p	ns	ns	ns	ns	ns	ns	**	ns	ns	***	ns	*
miR-195-5p	***	ns	****	**	***	**	ns	ns	ns	ns	ns	ns
miR-19b-3p	****	ns	****	****	****	****	*	ns	ns	ns	ns	ns
miR-204-5p,	**	ns	****	*	*	ns	***	*	ns	****	ns	ns
miR-20a-5p	****	ns	****	***	****	***	*	ns	ns	*	ns	ns
miR-21-5p	**	ns	****	****	****	****	**	ns	ns	*	ns	ns
miR-221-3p	**	ns	**	*	***	***	**	*	ns	****	ns	**
miR-223-3p	***	ns	****	****	****	****	**	ns	ns	****	ns	ns
miR-23a-3p	**	ns	***	**	***	***	**	*	ns	****	ns	*
miR-23b-3p	*	ns	ns	ns	ns	ns	**	*	ns	***	ns	*
miR-24-3p	***	ns	****	***	***	***	**	ns	ns	***	ns	*
miR-27a-3p	***	ns	****	*	**	****	**	ns	ns	***	ns	*
miR-27b-3p	***	ns	**	ns	ns	*	*	ns	ns	***	ns	*
miR-29a-3p	**	ns	***	****	****	***	**	ns	ns	**	ns	ns
miR-29b-3p	UD							*	ns	ns	ns	ns
miR-29c-3p	**	ns	**	*	***	**	*	ns	ns	ns	ns	ns
miR-34a-5p	**	ns	***	***	****	****	*	ns	*	ns	*	*
miR-34b-3p	**	ns	***	ns	ns	ns	ns	ns	**	ns	**	ns
miR-497-5p	***	ns	**	ns	**	**	****	ns	*	**	ns	ns
miR-874-3p	UD						UD
miR-9-5p	*	ns	ns	ns	ns	ns	UD
miR-92a-3p	***	ns	****	****	****	****		ns	ns	ns	ns	ns
nsmiR-124-3p	**	ns	**	*	**	*	UD
miR-451a	***	ns	*	ns	ns	ns	ns	ns	ns	ns	ns	ns

Custom brain and vasculature injury miRNA panel TLDA was used to analyze CSF and plasma specimens from Group A patients (8× DCV+, 10× DCV-, 8× HC). The differential expression was evaluated using Student’s t-test (2-tailed) between I: DCV+ vs. DCV-, PBD3; II: DCV+ vs. DCV-, PBD7; III: DCV+ vs. HC, PBD3; IV: DCV- vs. HC, PBD3; V: DCV+ vs. HC, PBD7; VI: DCV- vs. HC, PBD7. Asterisk symbols for significant levels: ****p < 0.0001; ***p = 0.0001–0.001; **p = 0.001–0.01; *p = 0.01–0.05; ns: p ≥ 0.05. UD, undetectable.