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. 2021 May 14;12:590201. doi: 10.3389/fphar.2021.590201

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Copyright © 2021 Jha, Sharma, Hashiesh, Arunachalam, Meeran, Javed, Patil, Goyal and Ojha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The structure and various polypharmacological properties and therapeutic potential of BCP. TNF-α, tumor necrosis factor alpha; IL, interleukin; PGE-2, prostaglandin E2; NO, nitric oxide; CINC-1, cytokine-induced neutrophil chemoattractant 1; NF-κB, nuclear factor kappa B; IFN-γ, interferon gamma; COX-2, cyclooxygenase-2; VCAM, vascular cell adhesion protein; iNOS, inducible nitric oxide synthase; GPx, glutathione peroxidase; SOD, superoxide dismutase; PPAR-γ, peroxisome proliferator-activated receptor gamma; PGC1-α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Nrf2, nuclear factor erythroid 2–related factor 2; FAS, fatty acid synthase; ATGL, adipose triglyceride lipase; ROS, reactive oxygen species; Bax, Bcl-2 associated X protein; Bcl-2, B-cell lymphoma 2; ART1, arginine ADP-ribosyltransferase 1; NFTs, neurofibrillary tangles; Aβ, amyloid beta; CB2R, cannabinoid receptor type 2.