Table 1.
Summary of Analyzed Datasets of Neuropsychiatric and Behavioral Traits
| Phenotype (Full Name) | Acronym | Female Cases (n) | Female Controls (n) | Male Cases (n) | Male Controls (n) | M:F Case Ratio | Sample Type | Consortium/Group | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Attention-Deficit/Hyperactivity Disorder | ADHD | 4945 | 16,246 | 14,154 | 17,948 | 2.86 | Clinical case-control | PGC+iPSYCH | (15) |
| Alcohol Dependence | ALCD | 2504 | 6033 | 5932 | 9412 | 2.37 | Clinical case-control | PGC | (16) |
| Anxiety Disorders | ANX | 3148 | 191,005 | 1813 | 165,175 | 0.58 | General population (UK) | Neale laboratory | (17) |
| Autism Spectrum Disorder | ASD | 7498 | 24,309 | 30,168 | 32,417 | 4.02 | Clinical case-control | PGC+iPSYCH | (18,19) |
| Bipolar Disorder | BD | 10,753 | 14,225 | 7331 | 13,572 | 0.68 | Clinical case-control | PGC2 | (20) |
| Cannabis Use (Ever) | CUE | 17,244 | 71,742 | 17,414 | 50,737 | 1.01 | General population (UK) | N/A | N/A |
| Insomnia | INS | 19,521 | 39,846 | 12,863 | 40,776 | 0.66 | General population (UK) | N/A | (21) |
| Major Depressive Disorder | MDD | 10,711 | 11,745 | 5021 | 11,226 | 0.47 | Clinical and population case-control | PGC1 | (20) |
| Major Depressive Disorder | N/Aa | 13,492 | 180,661 | 7156 | 159,832 | 0.53 | General population (UK) | Neale laboratory | (17) |
| Major Depressive Disorder Recurrent | MDDR | 6026 | 8949 | 2643 | 8162 | 0.44 | Clinical case-control | PGC1 | (20) |
| Obsessive-Compulsive Disorder | OCD | 1525 | 4307 | 1249 | 2789 | 0.82 | Clinical case-control | PGC | (22) |
| Posttraumatic Stress Disorder | PTSD | 968 | 2457 | 585 | 4025 | 0.60 | Clinical case-control | PGC | (23) |
| Risk-Taking Behavior | RTB | 32,285 | 143,678 | 51,392 | 100,984 | 1.59 | General population (UK) | N/A | (24) |
| Schizophrenia | SCZ | 9837 | 16,763 | 18,346 | 17,122 | 1.86 | Clinical case-control | PGC2 | (20) |
| Smoking (Current) | SMKC | 16,995 | 176,392 | 20,093 | 146,226 | 1.18 | General population (UK) | Neale laboratory | (17) |
| Smoking (Previous) | SMKP | 62,305 | 131,082 | 65,245 | 101,074 | 1.05 | General population (UK) | Neale laboratory | (17) |
| Females (n) | Males (n) | ||||||||
| Alcohol Use | ALCC | 59,088 | 53,088 | 0.90 | General population (UK) | (25) | |||
| Alcohol Use | N/Aa | 85,800 | 55,120 | 0.64 | General population | (26) | |||
| Age at First Birth | AFB | 189,656 | 48,408 | 0.26 | General population | (27) | |||
| Educational Attainment | EA | 182,286 | 146,631 | 0.80 | General population | (28) | |||
| Number of Children Ever Born | NEB | 225,230 | 103,909 | 0.46 | General population | (27) | |||
| Neuroticism | NEU | 144,660 | 142,875 | 0.99 | General population (UK) | (29) | |||
F, female; M, male; N/A, not applicable; PGC, Psychiatric Genomics Consortium; UK, United Kingdom.
a
These summary statistics were not used for analysis (see Sex-Stratified Datasets in Supplement 1 for details).