Table 2.

Top Results of Sex Differences in Cross-Trait Genetic Correlation Estimates

Trait 1	Trait 2	Females			Males			Sex Difference
		rg	SE	q ValueR	rg	SE	q ValueR	z Score	q Value
EA	RTB	0.187	0.033	6.38 × 10−8	−0.144	0.033	4.29 × 10−5	−8.353	7.98 × 10−15
AFB	RTB	−0.035	0.046	.52	−0.344	0.054	1.23 × 10−9	−4.906	5.58 × 10−5
EA	NEU	−0.22	0.029	1.72 × 10−13	−0.064	0.029	.051	4.421	3.94 × 10−4
CUE	NEU	−0.142	0.055	.022	0.124	0.054	.044	3.866	3.32 × 10−3
NEB	RTB	0.116	0.063	.12	0.413	0.074	1.43 × 10−7	3.582	8.19 × 10−3
ALCC	EA	0.276	0.047	2.52 × 10−8	0.043	0.049	.47	−3.53	8.30 × 10−3
SCZ	SMKC	0.034	0.045	.52	0.214	0.046	1.54 × 10−5	3.301	.013
ALCC	SMKC	0.013	0.058	.86	0.292	0.069	8.97 × 10−5	3.326	.013
BD	MDD	0.565	0.079	4.95 × 10−12	0.057	0.142	.74	−3.367	.013
RTB	SCZ	0.326	0.043	3.13 × 10−13	0.157	0.038	1.07 × 10−4	−3.088	.024
AFB	NEU	−0.173	0.037	1.44 × 10−5	−0.028	0.048	.63	2.95	.035

The z scores were calculated using equation 1.

AFB, age at first birth; ALCC, alcohol use; BD, bipolar disorder; CUE, cannabis use (ever); EA, educational attainment; MDD, major depressive disorder; NEB, number of children ever born; NEU, neuroticism; RTB, risk-taking behavior; SCZ, schizophrenia; SMKC, smoking (current).