Fig. 3. Evaporation of methanol droplets containing isatin and phenyl hydrazine (both 10 mM), calculated with eqn (1), and simultaneous reaction (eqn (3)). Time evolution of droplet diameter (a), reagent concentration in droplets and in bulk solution (grey dashed line) (b), product conversion ratio in droplets and in bulk solution (grey dashed line, right y-axis) (c) and calculated acceleration factor (d) for droplets with initial diameters of 200–4000 nm (purple to red color scale) are shown. The acceleration factors in (d) are calculated by dividing the conversion ratio in droplets and that in the bulk solution from panel (c) at each point in time. Reagents are considered non-volatile.