Fig. 8. Examples of cell cycle arrest by metallodrugs. Abrogation of the cell cycle enables the initiation of apoptosis to control cell proliferation. Metal complexes can inhibit cell cycle progression at different stages which vary between different cell lines, doses, and exposure times. The cell cycle checkpoints (pink) determine progression to the next stage, and cell cycle regulators include cyclins (green) and CDKs (cyclin-dependent kinases, blue). Subpopulations of cells enter a quiescent state at the G0 phase. CDDP (cisplatin, Pt1); l-OHP (oxaliplatin, Pt3); NAMI-A (Ru4); NKP1339 (Ru9); FY26 (Os4). Created with https://www.BioRender.com.