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. 2021 May 28;103:28–35. doi: 10.1016/j.reprotox.2021.05.007

Table 1.

Summary of fertility data from female rats administered control (saline) or BNT162b2.

Control (saline) BNT162b2
Fertility (n)a 44 44
Mean Estrous Cycle Length (days)b, c 4.02 ± 0.19 4.00 ± 0.11
Females with Acyclic Periodd 8/44 (18.2 %) 8/44 (18.2 %)
Days in Cohabitationb 3.0 ± 2.2 2.8 ± 1.7
Mating (Copulation) Indexe 44/44 (100 %) 44/44 (100 %)
Fertility Indexf 43/44 (98 %) 42/44 (95 %)
Pregnancy Rateg 43/44 (98 %) 42/44 (95 %)

*p ≤ 0.05, **p ≤ 0.001, (g) = grams.

a

Combined data from both cesarean section and delivery cohorts.

b

Data presented as mean per group ± standard deviation.

c

Estrous cycle length is determined by counting the days from the first day of estrous and the next cycle, and only complete cycles are counted. Estrous cycle length calculation excluded females with no complete cycles (acyclic) (n = 8 in control and BNT162b2 groups).

d

Any cycle with length > 6 days is considered an acyclic period, and females with no complete cycles were considered acyclic.

e

Calculated as number of mated females/number paired × 100.

f

Calculated as number pregnant/number paired × 100.

g

Calculated as number pregnant/number mated × 100.