Table 2.
Cesarean section observations and fetal weights from the female rats in the cesarean section cohort administered control (saline) or BNT162b2.
| Control (saline) | BNT162b2 | CRL-Lyon HC Mean (min–max)a | |
|---|---|---|---|
| C-Section Cohort (n)b | 21 | 21 | – |
| Gravid uterine weight (g) | 86.32 ± 7.69c | 87.65 ± 13.48 | 75.6 (64.6–86.8) |
| Corpora lutea | 14.7 ± 1.6 | 15.5 ± 2.1 | 13.2 (11.6–14.3) |
| Implantation sites | 14.1 ± 1.6 | 14.0 ± 2.2 | 12.1 (10.4–13.8) |
| Pre-implantation loss (%) | 4.09 ± 6.56 | 9.77 ± 8.09* | 8.4 (1.4–16.2) |
| Post-implantation loss (%) | 6.10 ± 7.64 | 5.85 ± 7.28 | 8.8 (2.4–17.3) |
| Number live fetuses | 13.2 ± 1.6 | 13.1 ± 2.1 | 11.0 (9.3–12.7) |
| Mean fetal body weight (g) | 4.89 ± 0.23 | 4.90 ± 0.30 | 5.09 (4.87–5.24) |
*
p ≤ 0.05, (g) = grams.
a
Historical control data for 24 studies from the test facility from years.2017–2018.
b
In this C-section cohort, 1 dam from each group was not pregnant.
c
Data presented as mean per group ± standard deviation.