Fig. 5. Fluorescence imaging by metallacycle 2in vivo. (A) Fluorescence imaging monitors the accumulation of metallacycle 2 in HeLa xenograft nude mice at different time points. (B) The biodistribution of metallacycle 2 in the main organs after 48 h and 72 h intravenous injection. (C) The distribution of metallacycle 2 (2 mg kg−1) in HeLa xenografts nude mice and 8 μm sections of tumor tissues. (D) Fluorescence intensity of metallacycle 2 in tumor sections analyzed by Image J. The HeLa xenograft nude mice were intravenously injected with 2 mg kg−1 of metallacycle 2.
