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Fig. 2. (a) Construction of metallo-nanodrugs through multicomponent (small peptides, photosensitizers, zinc ions) coordination self-assembly. (b) Ultrasensitive responsiveness of metallo-nanodrugs to pH and GSH. (c) Tumor growth profiles of mice after PDT. Reproduced with permission from ref. 7. Copyright 2018 American Chemical Society. (d) Spatiotemporally coupled photoactivity of PF self-assemblies for localized adaptive tumor theranostics. (e) Fluorescence spectra of PF NPs in the presence of DSPE-PEG2000 and in cell suspension. (f) Tumor growth profiles of mice after phototherapy. Reproduced with permission from ref. 42. Copyright 2019 Wiley VCH.