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. 2021 May 20;2021:8873383. doi: 10.1155/2021/8873383

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Copyright © 2021 Yoo-Wook Kwon et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Validation of HLA DR knockout iPSC immunogenicity. CD83-positive matured DC from HLA DR knockout iPSCs does not express HLA DR, and there is no response to the CD4 T cells. (a) FACS analysis showed the expression of CD83 and HLA DR for wild-type iPSC-derived DC vs. HLA DR knockout iPSC-derived DC. (b) MLR assay revealed that wild-type iPSC-derived DC significantly induced allogeneic lymphocyte activation compared with HLA DR knockout iPSC-derived DC. (The asterisks indicate statistically significant changes: ^∗P ≤ 0.5, ^∗∗P ≤ 0.01, N = 3).