Table 2.
Differentially expressed genes involved in nucleotide and NAD metabolism.
| Biological Process | Gene Symbol | Description | Fold Change | P Value |
|---|---|---|---|---|
| Nucleotide synthesis | RRM2 | Ribonucleotide reductase M2 | −1.3 | 0.018 |
| TK1 | Thymidine kinase 1, soluble | −1.3 | 0.001 | |
| PRPS1 | Phosphoribosyl pyrophosphate synthetase 1 | −1.2 | 0.008 | |
| PRPS2 | Phosphoribosyl pyrophosphate synthetase 2 | −1.3 | 0.004 | |
| PAICS | Phosphoribosylaminoimidazole carboxylase, | −1.3 | 0.031 | |
| GMPS | Guanine monophosphate synthase | −1.3 | 0.013 | |
| Nucleotide degradation | DYPD | Dihydropyrimidine dehydrogenase | 2.1 | 5.00E-05 |
| DYPS | Dihydropyrimidinase | 10.8 | 5.00E-05 | |
| NAD Synthesis | NMNAT3 | Nicotinamide Nucleotide adenylyltransferase 3 | 1.5 | 0.047 |
| AFMID | Arylformamidase | 1.3 | 0.017 | |
| QPRT | Quinolinate phosphoribosyltransferase | 1.3 | 0.017 |
A P-value cutoff ≤ 0.05, q-value cutoff ≤ 1 with |FC| ≥ 1 was used to determine differential expression (n = 3). complete list of genes analyzed for differential expression and additional details of analysis are included in Supplemental Table S1.