Table 2.

Summary of agonist potency order of shark A₀ determined from this study compared with potencies for A₁, A_2a, A_2b, and A₃ receptors from binding/functional studies in the literature

Receptor Subtype	Potency Order
Shark A0	R-PIA > 2ClAdo > NECA
A1	R-PIA > NECA > 2ClAdo
A2a	NECA > 2ClAdo > R-PIA
A2b	NECA > 2ClAdo > R-PIA
A3	R-PIA ≈ NECA

2ClAdo, 2-chloroadenosine; NECA, N-ethyl-carboxyl adenosine; R-PIA, R-phenyl-isopropyl adenosine. See expanded Supplemental Tables S7 and S8, including references.