Table 3.
Comparison of data from qualitative studies of shark A0 in Xenopus oocytes and functional studies of adenosine A1, A2a, A2b, and A3 receptor subtypes from the literature
| Subtype | Ag/Antag | Functional Profiles |
|---|---|---|
| A0 | Ag | R-PIA > S-PIA>CGS21680 > CPA > 2ClAdo > CV1808 ≥ DPMA > NECA |
| Antag | DPCPX > PD115199 > 8PT > CSC > CGS15943 | |
| A1 | Ag | CPA > R-PIA = CHA ≥ NECA > 2ClAdo > S-PIA > CV1808 ≥ CGS21680 |
| Antag | DPCPX > PD115199 > 8PT | |
| A2a | Ag | CGS21680 = NECA > CV1808 ≥ 2ClAdo>R-PIA = CHA = CPA > S-PIA |
| Antag | PD115199 > DPCPX = 8PT | |
| A2b | Ag | NECA > 2ClAdo > R-PIA = CHA > S-PIA ≥ CV1808 ≥ CGS21680 |
| Antag | DPCPX = 8PT ≥ PD115199 | |
| A3 | Ag | APNEA > R-PIA = NECA > CGS21680 |
| Antag | None identified in this review |
Ag, agonist; Antag, antagonist; 2ClAdo, 2-chloroadenosine; CPA, N6-cyclopentyladenosine; CSC, 8-(3-chlorostyryl)caffeine; DPCPX, 8-cyclopentyl-1,3-dipropylxanthine; DPMA, N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine; NECA, N-ethyl-carboxyl adenosine; R-PIA, R-phenyl-isopropyl adenosine; S-PIA, S-phenyl-isopropyl adenosine; 8PT, 1,3-dimethyl-8-phenylxanthine. See expanded Supplemental Tables S7 and S8, including references. Data adapted from Collis and Hourani (36).