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. 2021 May 24;13:4181–4189. doi: 10.2147/CMAR.S300195

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© 2021 Duan et al.

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USP8 depletion significantly enhances the inhibitory effects of standard of care drug in melanoma cells. USP8 knockdown significantly decreased growth and increased apoptosis in UACC-257 (A and C) and SK-MEL-28 (B and D) cells, and enhanced anti-proliferative and pro-apoptotic effect of vemurafenib (0.1 μM) and dacarbazine (1 μM). USP8 knockdown significantly decreased migration in UACC-257 (E) and SK-MEL-28 (F) cells. Results were presented as fold change relative to control. *P<0.05, compared to control.