Table 1.

Physical characteristics of 2 wk treated HbAA and HbSS mice

	HbAA		HbSS
	Control	Hydroxyurea	Control	Hydroxyurea
n	8	6	7	9
Body wt, g	27.3 ± 0.9	27.9 ± 0.7	27.4 ± 0.8	26.9 ± 0.5
Right kidney/body wt, mg/g	5.9 ± 0.2	5.2 ± 0.1	6.3 ± 0.5	6.4 ± 0.3
Left kidney/body wt, mg/g	5.9 ± 0.2	5.8 ± 0.2	6.2 ± 0.6	6.4 ± 0.3
Spleen-to-body wt ratio (%)	0.5 ± 0.1	0.4 ± 0.1	6.4 ± 0.4*	5.7 ± 0.3*

Data are presented as means ± SE; n, number of animals. *P < 0.05 vs. similarly treated HbAA group. HbAA, genetic control mice; HbSS, sickle cell disease mice.