Table 2.
Summary of the Main Studies on Sexual Dysfunction in IBD Patients
| Study | Design Study | Gender | Specific Disease | Patients | Questionnaire | Outcomes |
|---|---|---|---|---|---|---|
| Moody et al 199211 | Case control | F | CD | 50 CD/50 HC | The structured questionnaire | Infrequent or no intercourse vs HC due to symptoms |
| Timmer et al 200753 | Case control | M/F | CD/UC | Women: 222 IBD/181 controls Men: 186 IBD/153 controls |
BISF-W IIEF |
Women: total BISS-W score were lower in IBD vs HC Men: Total IIEF scores were not different between IBD vs HC Both, women and men, depression was the most important determinant of low sexual function in IBD |
| Marin et al 201313 | Case control | M/F | CD/UC | Women: 202 IBD/127 HC Men: 153 IBD/73 HC |
FSFI IIEF |
Lower scores in sexual indexes vs HC, but higher prevalence of SD was only noticed in women Main risk factors for low score IIEF: depression and diabetes |
| Bel et al 201514 | Case control | M/F | CD/UC | Women: 168 Men: 119 |
FSFI IIEF |
SD in women: 52% vs 44% HC. SD in men: 25% in both, IBD and HC, but higher SD with disease activity |
| Rivière et al 201712 | Cross-sectional (comparing IBD, HC and IBS) | M/F | CD/UC | Women: 192 IBD/54 HC/54 IBS Men: 166 IBD/56 HC/53 IBS |
FSFI IIEF |
SD in women: 54% (rates were significantly higher than HC) ED: 53.6% |
| Eluri et al 201827 | Cross-sectional | M/F | CD/UC | Women: 1824 Men: 745 |
PROMIS SexFS (Sexual function and satisfaction) |
Low sexual satisfaction in IBD patients vs general population |
| Schmidt et al 201932 | Prospective cohort | M | CD/UC | 82 men | IIEF | Global SD: 39% ED: 94% |
| Schmidt et al 201934 | Prospective cohort | F | CD/UC | 130 women | FSFI | SD: 97% DS did not improve over time despite improvement in disease activity |
| Nohr et al 202037 | Cross-sectional | F | CD/UC | 605 IBD women 37,406 non IBD women | Danish National Health Survey (adaptation) | CD patients had more difficulty achieving orgasm and increased dyspareunia vs non IBD |
Abbreviations: M, male; F, female; SD, sexual dysfunction; ED, erectile dysfunction; IBD, inflammatory bowel disease; CD, Crohn disease; UC, ulcerative colitis; IBS, irritable bowel disease; HC, health controls; IIEF, International Index for Erectile Function; FSFI, Female Sexual Function Index; PROMIS, Patient Reported Outcome Measurement Information System; Sex SF, sexual function and satisfaction questionnaire.