Figure 5.

Effect of e-cigarette vape (ECV) or tobacco cigarette smoking (TCS) exposures on phenylephrine (PhE)-mediated vasoconstriction. A and B: PhE-mediated constriction in aortic rings from mice exposed to air, e-cig, and TCS at 16 and 60 wk, respectively. Data are presented as means ± SE for 6 independent experiments for assessment of vascular reactivity. Increased PhE-mediated constriction was observed in all exposure groups compared with air control, with larger effect in the greatest effect in TCS and ECV-24 than in ECV-0 group. ECV-0, ECV with 0 mg/mL NIC; ECV-6, 6 mg/mL NIC; ECV-24, 24 mg/mL NIC; NIC, nicotine. *Significant difference from air-exposed control at P < 0.05; +significant difference from TCS-exposed group at P < 0.05.