Effects of leptin infusion on its circulating levels (A), cumulative food intake (B), maternal visceral fat mass (C), and maternal body weight (D) in Sham and RUPP rats. Sham or RUPP procedure plus leptin or vehicle infusion were started on GD 14 and measurements collected on GD 19. Data are presented as scattered-dot plots with mean ± SE. The results from the two-way ANOVA are inset. *P < 0.0001 for leptin effects within Sham or RUPP groups; #P < 0.0001 for differences between leptin-infused Sham and RUPP groups. ANOVA, analysis of variance; GD, gestational day; RUPP, reduced uterine perfusion pressure. Sham + Vehicle (N = 13), Sham + Leptin (N = 10), RUPP + Vehicle (N = 11), and RUPP + Leptin (N = 7).