Figure 4.

Effects of hyperleptinemia on mean arterial blood pressure (MAP) levels in Sham and RUPP rats. Sham or RUPP procedure plus leptin or vehicle infusion were conducted on GD 14 and measurements collected on GD 19 in conscious rats. Data are presented as scattered-dot plots with mean ± SE. The results from the two-way ANOVA are inset. *P < 0.0004 for Sham + Vehicle and RUPP + Vehicle groups; #P = 0.048 for differences between RUPP + Vehicle and RUPP + Leptin groups. ANOVA, analysis of variance; GD, gestational day; RUPP, reduced uterine perfusion pressure. Sham + Vehicle (N = 13), Sham + Leptin (N = 10), RUPP + Vehicle (N = 11), and RUPP + Leptin (N = 7).