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. 2021 Mar 12;320(5):H1949–H1958. doi: 10.1152/ajpheart.00724.2019

Figure 6.

Figure 6.

Effects of hyperleptinemia on mesenteric artery NOx content (A) and circulating NOx (B), cGMP (C), ANP (D), and BNP (E) levels in Sham and RUPP rats. Sham or RUPP procedure plus leptin or vehicle infusion were conducted on GD 14, and measurements were assessed in plasma or serum on GD 19. Data are presented as scattered-dot plots with mean ± SE. *P = 0.033 for differences in BNP levels between Sham + Vehicle vs. RUPP + Vehicle. The results from the two-way ANOVA are inset. ANOVA, analysis of variance; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; cGMP, cyclic guanosine monophosphate; GD, gestational day; NOx, nitrite + nitrate; RUPP, reduced uterine perfusion pressure. The number (N) of rats in each group were as follows: Sham + Vehicle (N = 8–13), Sham + Leptin (N = 5–10), RUPP + Vehicle (N = 8–11), and RUPP + Leptin (N = 3–7).