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. 2021 Apr 16;320(5):H2130–H2146. doi: 10.1152/ajpheart.00732.2020

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Figure 6. — Coimmunohistochemistry and confocal microscopy of Nebl^ex3-knockout (KO) hearts after exercise. A: vinculin (VCL; green) and DES (red) coexpression. In Nebl^+/+ mice, double-headed arrows indicate well-organized DES and VCL at focal adhesions adjacent to Z-disks (4th column). In Nebl^ex3-/ex3- hearts, diminished VCL (asterisks) is seen at fewer focal adhesions. Bar = 20 μm. B: nebulette (NEBL; green) and α-actinin2 (red) coexpression. In Nebl^+/+ mice, arrows indicate α-actinin2 and NEBL overlap (yellow) in well-organized Z-disks (4th column). In Nebl^ex3-/ex3- heart, disruption of α-actinin2 and NEBL is indicated by the asterisk. Bar = 10 μm.