The vasodysfunction theory for the usual pathogenesis of salt-induced increases in blood pressure. The initiation of salt-induced increases in blood pressure is hemodynamically mediated by an abnormal vascular resistance response to increases in salt intake, together with normal salt-induced increases in cardiac output. RVR, renal vascular resistance; SR, salt resistant; SS, salt sensitive; TPR, total peripheral resistance. Adapted from Kurtz et al. (2), with permission.