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. 2021 Mar 26;320(5):H2066–H2079. doi: 10.1152/ajpheart.00036.2021

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Copyright © 2021 The Authors

Licensed under Creative Commons Attribution CC-BY 4.0. Published by the American Physiological Society.

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Figure 1. — Pilot analysis of cardiac DNA methylation. A: multidimensional scaling (MDS) of top 10,000 cytosine-p-guanine (CpG) probes within the Illumina Human Methylation 450K array performed on cardiac left ventricle samples from patients with end-stage heart failure. The two principal components that account for the largest variance in DNA methylation were used to generate a scatterplot, flanked by density plots of each principal component. B: patient characteristics of cardiac samples used in the analysis. ACE-Inh, angiotensin-converting enzyme inhibitor; HF, heart failure; HTN, hypertension; LVEF left ventricular ejection fraction.