Table 1.

Enrichment analysis of inverse differences in gene expression and promoter methylation intensity

Enriched Pathway	Enrichment	P Value	Genes
Adipogenesis	5/130	0.003	CFD; CYP26B1; GATA3; PLIN1; SCD
Nuclear receptor pathway	7/319	0.009	CYP1A1; GGT1; MYC; NRG1; SCD; SLC39A4; TGFA
NRF2 signaling	4/146	0.02	GGT1; NRG1; SLC39A4; TGFA
T-cell antigen receptor signaling	3/90	0.03	CCR5; GATA3; LCP2
ErbB signaling	3/91	0.03	MYC; NRG1; TGFA

Pathways were sorted by Fisher’s exact test P value. Gene names formatted according to directionality of gene expression and methylation differences (bold = ↑DEGs, ↓DMCs; underline and italics = ↓DEGs, ↑DMCs). DEG, differentially expressed gene; DMC, differentially methylated CpG-probe.