Figure 5.

Exercise reduces aortic aneurysmal dilatation in BAPN-treated mice. Quantification of aortic lumen diameters by micro-CT imaging demonstrates a decrease in AscAo and DTA lumen size in BAPN-EX mice compared with BAPN-CONV mice. Exercise did not affect lumen size in BAPN-untreated animals. Dashed lines represent 1.5× the mean diameter of the relevant aortic segment in BAPN-untreated, conventional cage activity animals. *P < 0.05, **P < 0.01 by two-way ANOVA with Tukey’s multiple comparisons test. n = 10 CONV, 5 EX, 10 BAPN-CONV, 5 BAPN-EX. AscAo, ascending aorta; BAPN, β-aminopropionitrile; BAPN-CONV, conventional cage activity; BAPN-EX, forced treadmill exercise; DTA, descending thoracic aorta.