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. 2021 May 14;12:676403. doi: 10.3389/fendo.2021.676403

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Copyright © 2021 Zhang, Yang, Liu, Gao, Wang, Wang, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High glucose condition can increase the expression of c-Myc by activating the WNT/β-catenin pathway, which in turn initiates the transcription of c-Myc target gene S100A6, causing keratinocyte differentiation dysfunction.