Table 2.
Effects of nebivolol on the anti-electroshock action of valproate and phenytoin
| Treatment (mg/kg) | ED50 (mg/kg) | Statistics (ANOVA) |
|---|---|---|
| VPA + vehicle | 356.9 ± 14.92 | F (3.104) = 1.275; p = 0.2871 |
| VPA + NEB (5) | 320.2 ± 10.46 | |
| VPA + NEB (10) | 348.9 ± 13.71 | |
| VPA + NEB (15) | 353.1 ± 10.80 | |
| PHT + vehicle | 13.3 ± 1.52 | F (3.140) = 0.7035; p = 0.5514 |
| PHT + NEB (5) | 11.3 ± 0.72 | |
| PHT + NEB (10) | 14.3 ± 0.84 | |
| PHT + NEB (15) | 15.4 ± 0.93 | |
| PB + vehicle | 24.1 ± 1.84 | F (3.112) = 2.109; p = 0.1031 |
| PB + NEB (5) | 25.5 ± 2.03 | |
| PB + NEB (10) | 24.5 ± 1.92 | |
| PB + NEB (15) | 31.9 ± 1.23 |
Results are expressed as 50% effective doses (ED50) ± SEM
VPA valproate, PHT phenytoin, PB phenobarbital, NEB nebivolol