Table 3.
Effects of conventional antiepileptic drugs administered alone or in combinations with nebivolol on long-term memory and motor coordination
| Treatment (mg/kg) | Median (25, 75 percentiles) | Mice impaired (%) |
|---|---|---|
| Vehicle | 180 (178.6, 180) | 0 |
| NEB (15) | 47.2 (34.8, 118.2) | 0 |
| VPA (353) − ED50 | 29.4 (17.6, 100)** | 10 |
| VPA (353) + NEB (15) | 31 (19, 55)** | 30 |
| PHT (15.4) − ED50 | 44.4 (11.4, 180) | 0 |
| PHT (15.4) + NEB (15) | 27.6 (13.8, 69.8)* | 10 |
| CBZ (18.4) − ED50 | 46.5 (14.7, 65.2)* | 0 |
| CBZ (18.4) + NEB (15) | 35.2 (20.2, 91.9)* | 0 |
| PB (31.9) | 26.7 (19.9, 180) | 10 |
| PB (31.9) + NEB (15) | 46 (24.9, 154.5) | 10 |
Results are shown as percentage of animals showing motor deficits in the chimney test and as median retention times (with 25th and 75th percentiles in parentheses) observed in the step-through passive-avoidance task. Statistical analysis of data from the chimney test was performed with Fisher’s exact probability test, whilst data from the passive-avoidance test were evaluated by use of the Kruskal–Wallis nonparametric ANOVA test followed by the post hoc Dunn’s test. NEB, nebivolol; VPA, valproate; PHT, phenytoin; CBZ, carbamazepine; PB, phenobarbital
*p < 0.05, **p < 0.01 versus control (vehicle-treated mice). For detailed statistical data see chapter 3.3