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. 2021 May 28;7:122. doi: 10.1038/s41420-021-00505-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A AZD4320 alone inhibits MPM cell line viability, and this effect is enhanced by co-treatment with AZD5991. Cell viability was determined using CellTiter-Glo assays after 72 h treatment. Data represent mean ± SEM (n = 3). B Summary of EC₅₀ values for treatments in A. C Synergy analysis of BH3-mimetic drug combinations was performed with Combenefit software using the BLISS synergy model. Strong synergy was observed across a range of drug concentrations.