Fig. 2. Relationship between age at onset (AAO) and the lead single-nucleotide polymorphisms (SNPs) in the three independent regions identified in our genome-wide association study (GWAS).

a, b Two independent putative genetic loci on chromosome 5, the alternative alleles of which were found to accelerate disease onset. c The alternative allele of the chromosome 7 signal delays AAO in our patients. Box-plot elements: center line: median; box limits: upper and lower quartiles; whiskers: 1.5× interquartile range; single points: outliers. Source data are provided as a Source data file.