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. 2021 May 28;7:16. doi: 10.1038/s41514-021-00066-7

Fig. 5. Statistical analyses of age- and HF-associated remodeling of the t-system and RyR clusters.

Fig. 5

a Sarcolemmal distances were smaller in cardiomyocytes from donors than HF patients. b Effects of aging on the sarcolemmal distance were small in donors and not significant in HF patients. c The standard deviation of sarcolemmal distances was smaller in cardiomyocytes from donors than HF patients. d Standard deviations of the sarcolemmal distances were affected by age in donors. Effects were not significant in HF patients. e The density of RyR clusters was not different in donors and HF patients. f RyR cluster density was not affected by age. g The distance of RyR clusters to the sarcolemma was smaller in donors than HF patients. h Aging was associated with an increasing sarcolemmal distance of RyR clusters in donor cells. Effects of age on this distance were small in HF patients.