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. 2021 May 24;14:3353–3366. doi: 10.2147/OTT.S290284

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© 2021 Kuang et al.

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ALDOA promotes the tumor growth of PCa in nude mice in vivo and upregulates the expression of Ki67 and PCNA in the tumor tissues of nude mice. (A and C) Overexpression of ALDOA enhances tumor growth of DU145 and PC3 cells in the nude mice xenograft model. (B and D) Knockdown expression of ALDOA does not significantly inhibit tumor growth of DU145 and PC3 cells in the nude mice xenograft model. (E and F) The immunohistochemistry score for Ki67 and PCNA in tumor tissues resulting from ALDOA overexpression in PC3 and DU145 cell lines. (G and H) The immunohistochemistry score for Ki67 and PCNA in the tumor tissues resulting from ALDOA knockdown in PC3 and DU145 cell lines. Statistical analysis is shown as mean ±SD.*P < 0.05, **P < 0.01, ***P < 0.001 compared with the NC group.