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. 2021 May 28;12:3243. doi: 10.1038/s41467-021-23142-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Circos diagrams of significant interactions in chromosome III for the control (left) and methylated (right) samples. Heatmaps displaying the log2 ratio (Methylated/Control) of (b) the contact frequencies and (c) the distances in the ensemble for chromosome III. Blue indicates interaction with a higher frequency or shorter distance in the non-methylated control sample and red indicates interactions with a higher frequency or shorter distance in the methylated samples. d 3D representative structures for chromosome III highlighting the distance between MAT and HML loci shown in green. The centromere is represented as a blue sphere. e Average distances (±standard error) between mating type loci in the ensemble of structures for chromosome III (n = 260 and 482 structures for control and methylated samples, respectively). f Circos diagrams of significant interactions in chromosome XII for the control (left) and methylated (right) samples. Log2 ratio (Methylated/Control) of (g) the contact frequencies and (h) the distances in the ensemble for chromosome XII.