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. 2021 May 28;6:36. doi: 10.1038/s41525-021-00198-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The heterogenous presentation of telomere biology disorders manifestations may overlap and manifest at various time points or only following certain exposures or insults (e.g., radiation and immunosuppression as preconditioning regimens prior to bone marrow transplant may lead to pulmonary fibrosis in individuals who may have presented with isolated bone marrow failure). Regardless of clinical phenotype, patients are at increased risk of malignancies and disorders of premature aging. DC, dyskeratosis congenita; HHS, Hoyeraal–Hreidarsson Syndrome; ILD, interstitial lung disease; RS, Revesz Syndrome; TBD, telomere biology disorders.