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. 2021 Jan 21;15(6):1794–1809. doi: 10.1038/s41396-020-00887-6

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© The Author(s), under exclusive licence to International Society for Microbial Ecology 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 6 — PCE is dechlorinated to cDCE by S. multivorans with electrons from lactate oxidation. After depletion of PCE, S. multivorans switches to fermentative metabolism, thereby generating hydrogen, which is consumed by D. mccartyi as electron donor. The electron acceptor for D. mccartyi is cDCE and is further dechlorinated to ethene or VC by D. mccartyi. S. multivorans synthesizes norpseudo B₁₂ ([Ade]NCba, ) and [DMB]NCba () when DMB (maximally 1 µM) is amended. Both can be salvaged and remodeled by D. mccartyi into [DMB]Cba ( with a y-shaped linker). The interspecies cobamide transfer is indicated by yellow arrows. A discrimination between norcobamide or cobamide incorporation into the D. mccartyi RDases is not depicted here, since the data do not allow a conclusion on the cobalamin nucleotide loop type.

Inline graphic — PCE is dechlorinated to cDCE by S. multivorans with electrons from lactate oxidation. After depletion of PCE, S. multivorans switches to fermentative metabolism, thereby generating hydrogen, which is consumed by D. mccartyi as electron donor. The electron acceptor for D. mccartyi is cDCE and is further dechlorinated to ethene or VC by D. mccartyi. S. multivorans synthesizes norpseudo B₁₂ ([Ade]NCba, ) and [DMB]NCba () when DMB (maximally 1 µM) is amended. Both can be salvaged and remodeled by D. mccartyi into [DMB]Cba ( with a y-shaped linker). The interspecies cobamide transfer is indicated by yellow arrows. A discrimination between norcobamide or cobamide incorporation into the D. mccartyi RDases is not depicted here, since the data do not allow a conclusion on the cobalamin nucleotide loop type.