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. 2021 May 28;4:640. doi: 10.1038/s42003-021-02158-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Schematic to illustrate the distinct actions of MLN8237 and PROTAC-D on AURKA pools in mitotic cells. Both centrosomal and spindle pools of AURKA are inhibitable by MLN8237, whereas PROTAC-D clears the spindle pool of AURKA whilst leaving active AURKA at the centrosome. Figure made in ©BioRender (biorender.com).