Table 1.
Clinical and postmortem characteristic of the analytic cohort.
| Measure | Mean (SD) or number (%) |
|---|---|
| Clinical measures at last visit | |
| Age at death (years) | 89. 3 (6.51) |
| Females (%) | 811 (68.0%) |
| Education (years) | 16.2 (3.59) |
| Purdue pegboard test (no. of pegs/30 s) | 6.7 (3.37) |
| Finger-tapping test (taps/10 s) | 47.2 (14.57) |
| Time to cover a distance of 8 feet (seconds) | 6.0 (4.23) |
| Number of steps required to cover 8 feet (steps) | 9.0 (3.42) |
| 360 degree turn time (seconds) | 7.9 (6.33) |
| Number of steps to complete a 360° turn (steps) | 12.4 (5.69) |
| Leg stand (seconds) | 2.18 (2.77) |
| Toe stand (seconds) | 3.03 (3.54) |
| Grip strength (kilograms) | 32.4 (18.17) |
| Pinch strength (kilograms) | 8.14 (5.00) |
| Global motor measure | 0.67 (0.26) |
| Global parkinsonism score | 17.3 (11.58) |
| Instrumental activities of daily living disability | 1076 (90.3%) |
| Activity of daily living disability | 757 (63.5) |
| Mobility disability | 1038 (87.1) |
| Postmortem Indices | |
| Postmortem interval (hours) | 8.4 (6.04) |
| Nigral neuronal loss (moderate-severe) | 155 (13%) |
| Lewy bodies (any) | 316 (27%) |
| Pathologic Alzheimer's disease (NIA Reagan) | 766 (64%) |
| TDP-43 (present beyond amygdala) | 380 (32%) |
| Hippocampal Sclerosis (present) | 113 (9%) |
| Macroinfarcts present | 430 (36%) |
| Microinfarcts present | 337 (28%) |
| Atherosclerosis (moderate-severe) | 405(34%) |
| Arteriolosclerosis (moderate-severe) | 397 (33%) |
| Cerebral amyloid angiopathy (moderate-severe) | 422 (35%) |