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Local alignment of mdr1 wt and mutant mdr1 del4. Mdr1 wt from Canis lupus familiaris (Genebank accession number DQ068953.1) and mdr1 nt230 (del4) (Genebank accession number AJ419568.1) coding sequences as well as their transcripts were aligned. The nt230(del4) mdr1 deletion leads to a frame shift at amino acid position 75, resulting in a truncated, non-functional MDR1 protein due to the premature stop codon (TAA marked in red) after amino acid position 91.
